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 Creatine & DHT levels

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Posts : 1279
Join date : 2009-07-26
Age : 53
Location : UK

Creatine & DHT levels Empty
PostSubject: Creatine & DHT levels   Creatine & DHT levels EmptySun Feb 28, 2010 4:15 am

This study appears to show an acute raising of the testosterone metabolite dihydrotestosterone in male subjects, 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance. Now before everyone gets excited & rushes out to buy creatine although DHT is definitely involved in producing male characteristics it is not proven to increase muscle mass directly. It is however shown to encourage male pattern baldness & swelling of the prostrate gland, so it's not all good news getting elevated DHT levels. Another factor is how quickly, if at all these numbers return to baseline figures as the study is only for 3 weeks.
But I thought it was interesting as it shows that creatine can affect hormone balance & for those at risk of male pattern baldness it might actually be one supplement to miss out on. I'll paste the study below for those who don't like clicking all over the place.

Quote :
Clin J Sport Med. 2009 Sep;19(5):399-404.
Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.

van der Merwe J, Brooks NE, Myburgh KH.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

OBJECTIVE: This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation. DESIGN: Double-blind placebo-controlled crossover study with a 6-week washout period. SETTING: Rugby Institute in South Africa. PARTICIPANTS: College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season. INTERVENTIONS: Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo). MAIN OUTCOME MEASURES: Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point. RESULTS: After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01). CONCLUSIONS: Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition. STATEMENT OF CLINICAL RELEVANCE: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.
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